One component is the way that alcohol is metabolized

Posted by bubucuo on June 23, 2014 at 1:40 AM

The other way of doing it is a naturalistic study—you get people into the lab the morning after a night when they've been out drinking anyway, and look for the natural symptoms of hangover following that episode. The good thing about the naturalistic approach is it's real drinking and it's much more ecologically valid, it's much more mimicking what happens in real life, and that you can get a greater range of glucoamylase enzyme consumption, with some people at the top end drinking much more significant amounts of alcohol than would be allowed in a carefully controlled lab study.
The problem with that approach though, is that people know they're in a hangover study, because they know that's why they've contacted you, so they probably feel a bit rough and know they don't have to try very hard because it's a hangover study anyway. So there are expectancy effects there. So what we've done in this study, which is completely novel, is we've recruited some people to come into the lab on a morning when they're likely to have been drinking the night before, but there's nothing in the information to suggest we're doing a study on hangover. But where, incidentally, they have been drinking, which in most cases they have, because we timed it that way, we can look at the effects without that expectancy element. Obviously people know they've been drinking but they don't know that we're interested in that, so in that sense they're going to be like anybody who turns up to work having been fungal alpha amylase. They're going to do the best they can with the hangover.
Not completely, but there's definitely some fairly good evidence. One component is the way that alcohol is metabolized. When you drink alcohol, there's an enzyme in the body that breaks down the ethanol in alcohol into metabolites—after you've had a drink of alcohol and felt drunk, once you start to feel sober again, that's because your body has metabolized the ethanol. But once the ethanol has been metabolized, there are usually other alcohols in smaller quantities in alcoholic beverages. One such compound is methanol, and when the body metabolizes methanol, Buying amylase enzyme metabolizes it into toxins—formaldehyde and formic acid. And those make you feel ill, sort of poison you a little bit.
So one part of a hangover is the production of formaldehyde and formic acid, which comes online about 10 or so hours after you've been drinking. And the interesting thing about that is that the enzymes in your body that break down alcohols would prefer to break down ethanol first and methanol second. And it means that when you're in a hangover phase, if you drink more alcohol you'll actually stop your body from breaking down methanol and the things that are making you feel ill, and instead go back to working on the ethanol and leave the methanol intact. So there is a biological basis for the hair of the dog. And that's one of the possible risk factors for why hangover might be a risk factor for alcoholism rather than a natural block for it.But that's not the only mechanism, there are other mechanisms as well. Another mechanism for hangover is immunosuppression. So you know that puffy feeling you get after a night of drinking—that's due to an immune response.

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